- Andrew Lincoln as Rick Grimes
- Sarah Wayne Callies as Lori Grimes
- Laurie Holden as Andrea Harrison
- Norman Reedus as Daryl Dixon
- Steven Yeun as Glenn Rhee
- Lauren Cohan as Maggie Greene
- Chandler Riggs as Carl Grimes
- Madison McLaughlin as Evelyn Grimes
- Danai Gurira as Michonne
- Michael Rooker as Merle Dixon
- David Morrissey as Philip Blake
- Lori Grimes is the third main character to die.
- Merle Dixon is the fourth main character to die.
- Andrea Harrison is the fifth main character to die.