Season 3 (Infections)

Main

 * Nina Dobrev - Monica Evans
 * Jensen Ackles - Shawn Zacks
 * Rutina Wesley - Kaya Dutch
 * Leigh Allyn Baker - Sarah Walters
 * Dove Cameron - Melanie
 * Tanner Holland - Chase
 * Emily Kinney - Danni Bleu
 * Billie Lourd - Jane
 * James Allen McCune - Wes
 * Jennette McCurdy - Abby Walters
 * Dylan O'Brien - Jake
 * Carlos Penavega - Mikel
 * Ving Rhames - Mike Monroe

Reccurring

 * Neil Patrick Harris - Jason West (?)
 * Melanie Martinez - MacKenzie Jameson (?)
 * Mary Scheer - Diane
 * Jennifer Aniston - Skylar Bleu
 * Connie Britton - Hannah
 * Victoria Justice - Savanah
 * Ryan Kwanten - Marco
 * Halle Berry - Vivian
 * Keke Palmer - Jenna

Trivia

 * Dove Cameron, Tanner Holland, Emily Kinney, James Allen McCune, Dylan O'Brien and Carlos Penavega have all been upgraded to series regulars.
 * Neil Patrick Harris and Melanie Martinez are rumored to return as their characters.